Próximo(s)

Función del magnesio en la salud mental: revisión de la evidencia sobre la depresión, ansiedad, sueño y cognición

Autores/as

  • Evelyn Velázquez-Gómez Universidad de Guadalajara, Centro Universitario de los Altos, Licenciatura en Químico Farmacéutico Biólogo, Tepatitlán de Morelos, Jalisco, México, C. P. 47620. https://orcid.org/0009-0006-3061-6844
  • Alejandro Pérez-Larios Universidad de Guadalajara, Centro Universitario de los Altos, Departamento de Ingenierías, Laboratorio de Investigación en Nanocatálisis, Tepatitlán de Morelos, Jalisco, México, C. P. 47620. https://orcid.org/0000-0001-8656-5667
  • Monserrat Macías-Carballo  Universidad de Guadalajara, Centro Universitario de los Altos, Departamento de Ciencias de la Salud, Instituto de Investigación en Biociencias, Av. Rafael Casillas Aceves núm. 1200, C. P 47620, Tepatitlán de Morelos, Jalisco, México. https://orcid.org/0009-0002-2546-9262

DOI:

https://doi.org/10.29059/cienciauat.v20i2.2070

Palabras clave:

magnesio, salud mental, depresión, ansiedad, declive cognitivo

Resumen

El magnesio a nivel del sistema nervioso central, desempeña funciones cruciales en la transmisión sináptica y la modulación de neurotransmisores. El objetivo del presente trabajo fue analizar la evidencia científica actual sobre el papel del magnesio en la salud mental y su relación con trastornos y tratamientos de alteraciones mentales. La metodología de la presente revisión narrativa se basó en la búsqueda de información en las bases de datos PubMed y ScienceDirect, abarcando el periodo de febrero de 2015 a agosto de 2025, complementada con un rastreo retrospectivo de referencias usando Google Académico como apoyo. Se seleccionaron e incluyeron 65 artículos (estudios clínicos y revisiones) que evaluaron el impacto del mineral en la depresión, ansiedad, sueño y cognición, como también un documento técnico del Instituto Nacional del Cáncer y otro documento técnico del Instituto Nacional de Salud. La literatura demuestra una asociación entre la deficiencia de magnesio con el desarrollo de depresión, ansiedad, trastornos del sueño y deterioro cognitivo, mientras que su suplementación muestra efectos beneficiosos en la prevención y tratamiento de estas alteraciones. En conjunto, el magnesio representa una estrategia complementaria prometedora en el abordaje de la salud mental, respaldado por su capacidad para modular vías neurobiológicas clave; sin embargo, se requieren dosis estandarizadas para optimizar su uso clínico.

Citas

Agnihotri, S., Daripelly, S., Cherla, S. K., Jopaka, A. K., & Molanguri, U. (2024). Association of biomarkers with the severity of depression. Indian Journal of Psychological Medicine. Advance online publication. https://doi.org/10.1177/02537176241264609 DOI: https://doi.org/10.1177/02537176241264609

Aly, J. & Engmann, O. (2020). The way to a human's brain goes through their stomach: Dietary factors in major depressive disorder. Frontiers in Neuroscience, 14, 582853. https://doi.org/10.3389/fnins.2020.582853 DOI: https://doi.org/10.3389/fnins.2020.582853

Angelow, S., Ahlstrom, R., & Yu, A. S. L. (2008). Biology of claudins. American Journal of Physiology-Renal Physiology, 295(4), F867–F876. https://doi.org/10.1152/ajprenal.90264.2008 DOI: https://doi.org/10.1152/ajprenal.90264.2008

Anjom-Shoae, J., Sadeghi, O., Hassanzadeh-Keshteli, A., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2018). The association between dietary intake of magnesium and psychiatric disorders among Iranian adults: A cross-sectional study. British Journal of Nutrition, 120(6), 693-702. https://doi.org/10.1017/S0007114518001782 DOI: https://doi.org/10.1017/S0007114518001782

Bautista-Charry, A. A. (2024). Sulfato de magnesio: 100 años salvando vidas maternas. Un patrimonio científico de la humanidad. Revista Colombiana de Obstetricia y Ginecología, 75(3). https://doi.org/10.18597/rcog.4303 DOI: https://doi.org/10.18597/rcog.4303

Boyle, N. B., Lawton, C., & Dye, L. (2017). The effects of magnesium supplementation on subjective anxiety and stress—A systematic review. Nutrients, 9(5), 429. https://doi.org/10.3390/nu9050429 DOI: https://doi.org/10.3390/nu9050429

Clark, B. A. & Brown, R. S. (1992). Unsuspected morbid hypermagnesemia in elderly patients. American Journal of Nephrology, 12(5), 336-343. https://doi.org/10.1159/000168469 DOI: https://doi.org/10.1159/000168469

Devarshi, P. P., Gustafson, K., Grant, R. W., & Mitmesser, S. H. (2023). Higher intake of certain nutrients among older adults is associated with better cognitive function: an analysis of NHANES 2011-2014. BMC Nutrition, 9(1). https://doi.org/10.1186/s40795-023-00802-0 DOI: https://doi.org/10.1186/s40795-023-00802-0

Ðurić, V., Batinić, B., Petrović, J., Stanić, D., Bulat, Z., & Pešić, V. (2018). A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. Magnesium Research, 31(1), 24-32. https://doi.org/10.1684/mrh.2018.0435 DOI: https://doi.org/10.1684/mrh.2018.0435

Ekinci, G. N. & Sanlier, N. (2023). The relationship between nutrition and depression in the life process: A mini-review. Experimental Gerontology, 172, 112072. https://doi.org/10.1016/j.exger.2022.112072 DOI: https://doi.org/10.1016/j.exger.2022.112072

Fassin, M., Danhier, P., & Ris, L. (2020). Effect of oral administration of magnesium n-acetyltaurinate on synaptic plasticity in rodents. Magnesium Research, 33(4), 106–113. https://doi.org/10.1684/mrh.2021.0475 DOI: https://doi.org/10.1684/mrh.2021.0475

Fiorentini, D., Cappadone, C., Farruggia, G., & Prata, C. (2021). Magnesium: Biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients, 13(4). https://doi.org/10.3390/nu13041136 DOI: https://doi.org/10.3390/nu13041136

García-Maldonado, E., Gallego-Narbón, A., Zapatera, B., Alcorta, A., Martínez-Suárez, M., & Vaquero, M. P. (2024). Bone remodelling, vitamin D status, and lifestyle factors in Spanish vegans, lacto-ovo vegetarians, and omnivores. Nutrients, 16(3), 448. https://doi.org/10.3390/nu16030448 DOI: https://doi.org/10.3390/nu16030448

Górska, N., Słupski, J., Szałach, Ł. P., Włodarczyk, A., Szarmach, J., Jakuszkowiak-Wojten, K., Gałuszko-Węgielnik, M., Wilkowska, A., Wiglusz, M. S., & Cubała, W. J. (2019). Magnesium and ketamine in the treatment of depression. Psychiatria Danubina, 31(Suppl 3), 549–553.

Gröber, U., Schmidt, J., & Kisters, K. (2015). Magnesium in prevention and therapy. Nutrients, 7(9), 8199-8226. https://doi.org/10.3390/nu7095388 DOI: https://doi.org/10.3390/nu7095388

Hausenblas, H. A., Lynch, T., Hooper, S., Shrestha, A., Rosendale, D., & Gu, J. (2024). Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Medicine: X, 8. https://doi.org/10.1016/j.sleepx.2024.100121 DOI: https://doi.org/10.1016/j.sleepx.2024.100121

Hoepner, C. T., McIntyre, R. S., & Papakostas, G. I. (2021). Impact of supplementation and nutritional interventions on pathogenic processes of mood disorders: A review of the evidence. Nutrients, 13(3), 1-25. https://doi.org/10.3390/nu13030767 DOI: https://doi.org/10.3390/nu13030767

Hosgorler, F., Koc, B., Kizildag, S., Canpolat, S., Argon, A., Karakilic, A., Kandis, S., Guvendi, G., Ates, M., Arda, N. M., & Uysal, N. (2020). Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats. Turkish Neurosurgery, 30(5), 723–733. https://doi.org/10.5137/1019-5149.JTN.29272-20.1 DOI: https://doi.org/10.5137/1019-5149.JTN.29272-20.1

International Federation of Clinical Chemistry and Laboratory Medicine (1999). Disorders of magnesium metabolism. EJIFCC, 11(2), 36–44. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357249/

Kirkland, A. E., Sarlo, G. L., & Holton, K. F. (2018). The role of magnesium in neurological disorders. Nutrients, 10(6). https://doi.org/10.3390/nu10060730 DOI: https://doi.org/10.3390/nu10060730

Kröse, J. L. & de-Baaij, J. H. F. (2024). Magnesium biology. Nephrology Dialysis Transplantation, 39(12), 1965-1975. https://doi.org/10.1093/ndt/gfae134 DOI: https://doi.org/10.1093/ndt/gfae134

Leenders, N. H. J., Vermeulen, E. A., van-Ballegooijen, A. J., Hoekstra, T., de-Vries, R., Beulens, J. W., & Vervloet, M. G. (2021). The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis. Clinical Nutrition, 40(5), 3133-3147. https://doi.org/10.1016/j.clnu.2020.12.015 DOI: https://doi.org/10.1016/j.clnu.2020.12.015

Lopresti, A. L. & Smith, S. J. (2026). The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Frontiers in Nutrition, 12, 1729164. https://doi.org/10.3389/fnut.2025.1729164 DOI: https://doi.org/10.3389/fnut.2025.1729164

Macías-Carballo, M., Rosas-Navarro, S., López-Meraz, M. L., Beltran-Parrazal, L., & Morgado-Valle, C. (2021). Anxiolytic effect of chronic intake of supplemental magnesium chloride in rat. Behavioural Brain Research, 413. 113460. https://doi.org/10.1016/j.bbr.2021.113460 DOI: https://doi.org/10.1016/j.bbr.2021.113460

Maguire, D., Neytchev, O., Talwar, D., McMillan, D., & Shiels, P. G. (2018). Telomere Homeostasis: Interplay with Magnesium. International Journal of Molecular Sciences, 19(1), 157. https://doi.org/10.3390/ijms19010157 DOI: https://doi.org/10.3390/ijms19010157

Martínez-Cengotitabengoa, M. & González-Pinto, A. (2017). Nutritional supplements in depressive disorders. Actas Españolas de Psiquiatría, 45(Suppl. 1), 79-85.

McCabe, D., Lisy, K., Lockwood, C., & Colbeck, M. (2017). The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: A systematic review. JBI Database of Systematic Reviews and Implementation Reports, 15(2), 402-453. https://doi.org/10.11124/JBISRIR-2016-002965 DOI: https://doi.org/10.11124/JBISRIR-2016-002965

Młyniec, K., Gaweł, M., Doboszewska, U., Starowicz, G., & Nowak, G. (2017). The role of elements in anxiety. Vitamins and Hormones, 103,295-326. https://doi.org/10.1016/bs.vh.2016.09.002 DOI: https://doi.org/10.1016/bs.vh.2016.09.002

Moabedi, M., Aliakbari, M., Erfanian, S., & Milajerdi, A. (2023). Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials. Frontiers in Psychiatry, 14, 1333261. https://doi.org/10.3389/fpsyt.2023.1333261 DOI: https://doi.org/10.3389/fpsyt.2023.1333261

Moncayo, R. & Moncayo, H. (2014). The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation. BBA Clinical, 3, 44–64. https://doi.org/10.1016/j.bbacli.2014.11.002 DOI: https://doi.org/10.1016/j.bbacli.2014.11.002

Mori, H., Tack, J., & Suzuki, H. (2021). Magnesium oxide in constipation. Nutrients, 13(2), 421. https://doi.org/10.3390/nu13020421 DOI: https://doi.org/10.3390/nu13020421

Mudryk, K., Lee, C., Tomaník, L., Malerz, S., Trinter, F., Hergenhahn, U., Neumark, D. M., Slavíček, P., Bradforth, S., & Winter, B. (2024). How does Mg2+(aq) interact with ATP(aq)? Biomolecular structure through the lens of liquid-jet photoemission spectroscopy. Journal of the American Chemical Society, 146(23), 16062–16075. https://doi.org/10.1021/jacs.4c03174 DOI: https://doi.org/10.1021/jacs.4c03174

Musso, C. G. (2009). Magnesium metabolism in health and disease. International Urology and Nephrology, 41(2), 357-362. https://doi.org/10.1007/s11255-009-9548-7 DOI: https://doi.org/10.1007/s11255-009-9548-7

National Cancer Institute (2006). Common terminology criteria for adverse events (CTCAE) v3.0. U.S. Department of Health and Human Services. https://dctd.cancer.gov/research/ctep-trials/for-sites/adverse-events/ctcae-v3.pdf

National Institutes of Health / Office of Dietary Supplements (2026). Magnesium: Fact sheet for health professionals. [En línea]. Disponible en: https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Fecha de consulta: 16 de junio de 2026.

Neufingerl, N. & Eilander, A. (2022). Nutrient intake and status in adults consuming plant-based diets compared to meat-eaters: A systematic review. Nutrients, 14(1). https://doi.org/10.3390/nu14010029 DOI: https://doi.org/10.3390/nu14010029

Noah, L., Morel, V., Bertin, C., Pouteau, E., Macian, N., Dualé, C., Pereira, B., & Pickering, G. (2022). Effect of a combination of magnesium, B vitamins, rhodiola, and green tea (L-Theanine) on chronically stressed healthy individuals—A randomized, placebo-controlled study. Nutrients, 14(9). https://doi.org/10.3390/nu14091863 DOI: https://doi.org/10.3390/nu14091863

Noordam, R., Young, W. J., Salman, R., Kanters, J. K., van-den-Berg, M. E., van-Heemst, D., Lin, H. J., Barreto, S. M., Biggs, M. L., Biino, G., Catamo, E., Concas, M. P., Ding, J., Evans, D. S., Foco, L., Grarup, N., Lyytikäinen, L. P., Mangino, M., Mei, H., ..., & Warren, H. R. (2019). Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals. Journal of the American College of Cardiology, 73(24), 3118-3131. https://doi.org/10.1016/j.jacc.2019.03.519 DOI: https://doi.org/10.1016/j.jacc.2019.03.519

Panczyszyn-Trzewik, P., Misztak, P., Opoka, W., Nowak, G., & Sowa-Kucma, M. (2023). Oxidative stress responses and their alterations in the NRF2-NMDA receptor pathway in the brain of suicide victims. Journal of Physiology and Pharmacology, 74(3), 335-346. https://doi.org/10.26402/jpp.2023.3.08

Pardo, M. R., Garicano-Vilar, E., San-Mauro-Martín, I., & Camina-Martín, M. A. (2021). Bioavailability of magnesium food supplements: A systematic review. Nutrition, 89, Article 111294. https://doi.org/10.1016/j.nut.2021.111294 DOI: https://doi.org/10.1016/j.nut.2021.111294

Pyndt-Jørgensen, B., Winther, G., Kihl, P., Nielsen, D. S., Wegener, G., Hansen, A. K., & Sørensen, D. B. (2015). Dietary magnesium deficiency affects gut microbiota and anxiety-like be-haviour in C57BL/6N mice. Acta Neuropsychiatrica, 27(5), 307-311. https://doi.org/10.1017/neu.2015.10 DOI: https://doi.org/10.1017/neu.2015.10

Ross, K., van-Nortwick, M., & Dragone, D. (2021). Innovative therapies for mood disorders: A case report. Explore, 17(3), 208-212. https://doi.org/10.1016/j.explore.2020.03.011 DOI: https://doi.org/10.1016/j.explore.2020.03.011

Santomauro, D. F., Mantilla Herrera, A. M., Shadid, J., Zheng, P., Ashbaugh, C., Pigott, D. M., Abbafati, C., Adolph, C., Amlag, J. O., Aravkin, A. Y., Bang-Jensen, B. L., Bertolacci, G. J., Bloom, S. S., Castellano, R., Castro, E., Chakrabarti, S., Chattopadhyay, J., Cogen, R. M., Collins, J. K., ..., & Ferrari, A. J. (2021). Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. The Lancet, 398(10312), 1700-1712. https://doi.org/10.1016/S0140-6736(21)02143-7 DOI: https://doi.org/10.1016/S0140-6736(21)02143-7

Schlingmann, K. P., Waldegger, S., Konrad, M., Chubanov, V., & Gudermann, T. (2007). TRPM6 and TRPM7. Gatekeepers of human magnesium metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1772(8), 813–821. https://doi.org/10.1016/j.bbadis.2007.03.009 DOI: https://doi.org/10.1016/j.bbadis.2007.03.009

Schuchardt, J. P. & Hahn, A. (2017). Intestinal absorption and factors influencing bioavailability of magnesium- An update. Current Nutrition and Food Science, 13(4). https://doi.org/10.2174/1573401313666170427162740 DOI: https://doi.org/10.2174/1573401313666170427162740

Serefko, A., Lachowicz-Radulska, J., Szopa, A., Herbet, M., Czylkowska, A., Ignatiuk, K., Dołoto, A., Szewczyk, B., Wośko, S., Wróbel, A., Szponar, J., Wlaź, P., Skałecki, P., Wróbel, J., Słotwińska, W., & Poleszak, E. (2025). The novel imipramine–magnesium complex exe-rts antidepressant-like activity in mice subjected to the forced swim test and the tail suspension test. Molecules, 30(3). https://doi.org/10.3390/molecules30030519 DOI: https://doi.org/10.3390/molecules30030519

Shindo, Y., Yamanaka, R., Hotta, K., & Oka, K. (2020). Inhibition of Mg2+ extrusion attenuates glutamate excitotoxicity in cultured rat hippocampal neurons. Nutrients, 12(9), 1-14. https://doi.org/10.3390/nu12092768 DOI: https://doi.org/10.3390/nu12092768

Shrivastava, P., Choudhary, R., Nirmalkar, U., Singh, A., Shree, J., Vishwakarma, P. K., & Bodakhe, S. H. (2018). Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats. Journal of Traditional and Complementary Medicine, 9(2), 119–123. https://doi.org/10.1016/j.jtcme.2017.06.010 DOI: https://doi.org/10.1016/j.jtcme.2017.06.010

Skalski, M., Mach, A., Januszko, P., Ryszewska-Pokraśniewicz, B., Biernacka, A., Nowak, G., Pilc, A., Poleszak, E. & Radziwoń-Zaleska, M. (2021). Pharmaco-electroencephalography-based assessment of antidepressant drug efficacy—the use of magnesium ions in the treatment of depression. Journal of Clinical Medicine, 10(14). https://doi.org/10.3390/jcm10143135 DOI: https://doi.org/10.3390/jcm10143135

Stachowicz, K. (2023). Regulation of COX-2 expression by selected trace elements and heavy metals: Health implications, and changes in neuronal plasticity. A review. Journal of Trace Elements in Medicine and Biology, 79, 127226. https://doi.org/10.1016/j.jtemb.2023.127226 DOI: https://doi.org/10.1016/j.jtemb.2023.127226

Strodl, E., Bambling, M., Parnam, S., Ritchie, G., Cramb, S., & Vitetta, L. (2024). Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-71093-z DOI: https://doi.org/10.1038/s41598-024-71093-z

Sultana, S., Anwar Sonia, S. B., Rumu, H., Jhumu, S., Wahid, S. B., & Chowdhury, I. H. (2025). Association between serum magnesium level and depression in selective serotonin reuptake inhibitors treated major depressive disorder patients. Mugda Medical College Journal, 8(2), 138–144. https://doi.org/10.3329/mumcj.v8i2.85808 DOI: https://doi.org/10.3329/mumcj.v8i2.85808

Szkup, M., Jurczak, A., Brodowska, A., Brodowska, A., Noceń, I., Chlubek, D., Laszczyńska, M., Karakiewicz, B., & Grochans, E. (2017). Analysis of relations between the level of Mg, Zn, Ca, Cu, and Fe and Depressiveness in Postmenopausal Women. Biological Trace Element Research, 176(1), 56-63. https://doi.org/10.1007/s12011-016-0798-9 DOI: https://doi.org/10.1007/s12011-016-0798-9

Tarleton, E. K., Kennedy, A. G., Rose, G. L., Crocker, A., & Littenberg, B. (2019). The association between serum magnesium levels and depression in an adult primary care population. Nutrients, 11(7). https://doi.org/10.3390/nu11071475 DOI: https://doi.org/10.3390/nu11071475

Tarleton, E. K., Littenberg, B., MacLean, C. D., Kennedy, A. G., & Daley, C. (2017). Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PloS One, 12(6), e0180067. https://doi.org/10.1371/journal.pone.0180067 DOI: https://doi.org/10.1371/journal.pone.0180067

Uysal, N., Kizildag, S., Yuce, Z., Guvendi, G., Kandis, S., Koc, B., Karakilic, A., Camsari, U. M. & Ates, M. (2019). Timeline (bioavailability) of magnesium compounds in hours: Which magnesium compound works best? Biological Trace Element Research, 187(1), 128-136. https://doi.org/10.1007/s12011-018-1351-9 DOI: https://doi.org/10.1007/s12011-018-1351-9

Van-Laecke, S. (2024). An update on hypomagnesemia and hypermagnesemia. Kidney and Dialysis, 4(1), 1-14. https://doi.org/10.3390/kidneydial4010001 DOI: https://doi.org/10.3390/kidneydial4010001

Van-Winden, T., Roos, C., Mol, B. W., Pajkrt, E., & Oudijk, M. A. (2024). A historical narrative review through the field of tocolysis in threatened preterm birth. European Journal of Obstetrics and Gynecology and Reproductive Biology: X, 22, 100313. https://doi.org/10.1016/j.eurox.2024.100313 DOI: https://doi.org/10.1016/j.eurox.2024.100313

Wang, J., Um, P., Dickerman, B. A., & Liu, J. (2018). Zinc, magnesium, selenium and depression: A review of the evidence, potential mechanisms and implications. Nutrients, 10(5), 584. https://doi.org/10.3390/nu10050584 DOI: https://doi.org/10.3390/nu10050584

Wang, Q., Hu, Y., Li, F., Hu, L., Zhang, Y., Qiao, Y., Tang, C., & Wang, R. (2025). MgSO4 alleviates hippocampal neuroinflammation and BBB damage to resist CMS-induced depression. Frontiers in Nutrition, 12, 1470505. https://doi.org/10.3389/fnut.2025.1470505 DOI: https://doi.org/10.3389/fnut.2025.1470505

Weder, S., Keller, M., Fischer, M., Becker, K., & Alexy, U. (2022). Intake of micronutrients and fatty acids of vegetarian, vegan, and omnivorous children (1-3 years) in Germany (VeChi Diet Study). European Journal of Nutrition, 61(3), 1507–1520. https://doi.org/10.1007/s00394-021-02753-3 DOI: https://doi.org/10.1007/s00394-021-02753-3

Winther, G., Pyndt Jørgensen, B. M., Elfving, B., Nielsen, D. S., Kihl, P., Lund, S., Sorensen, D. B., & Wegener, G. (2015). Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour. Acta Neuropsychiatrica, 27(3), 168-176. https://doi.org/10.1017/neu.2015.7 DOI: https://doi.org/10.1017/neu.2015.7

Yary, T., Lehto, S. M., Tolmunen, T., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Ruusunen, A. (2016). Dietary magnesium intake and the incidence of depression: A 20-year follow-up study. Journal of Affective Disorders, 193, 94-98. https://doi.org/10.1016/j.jad.2015.12.056 DOI: https://doi.org/10.1016/j.jad.2015.12.056

Zhang, J., Mai, C. L., Xiong, Y., Lin, Z. J., Jie, Y. T., Mai, J. Z., Liu, C., Xie, M. X., Zhou, X., & Liu, X. G. (2021). The causal role of magnesium deficiency in the neuroinflammation, pain hypersensitivity and memory/emotional deficits in ovariectomized and aged female mice. Journal of Inflammation Research, 14, 6633-6656. https://doi.org/10.2147/JIR.S330894 DOI: https://doi.org/10.2147/JIR.S330894

Zhang, Y., Chen, C., Lu, L., Knutson, K. L., Carnethon, M. R., Fly, A. D., Luo, J., Haas, D. M., Shikany, J. M., & Kahe, K. (2022). Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study. Sleep, 45(4). https://doi.org/10.1093/sleep/zsab276 DOI: https://doi.org/10.1093/sleep/zsab276

Zhang, Z., Chen, X., Wu, S., Chen, X., Wang, X., Liu, C., Zeng, N., Liu, Y., Huo, T., Liu, X., Shi, L., Yan, W., Yuan, K., Meng, S., Wu, P., Javed, A., Alibudbud, R., Shi, J., Sun, Y., Lu, L., …, & Bao, Y. (2026). Global, regional and national burden of anxiety and depression disorders from 1990 to 2021, and forecasts up to 2040. Journal of Affective Disorders, 393(Pt A), 120299. https://doi.org/10.1016/j.jad.2025.120299 DOI: https://doi.org/10.1016/j.jad.2025.120299

Zhou, X., Huang, Z., Zhang, J., Chen, J. L., Yao, P. W., Mai, C. L., Mai, J. Z., Zhang, H., & Liu, X. G. (2020). Chronic oral administration of magnesium-L-threonate prevents oxaliplatin-induced memory and emotional deficits by normalization of TNF-α/NF-κB signaling in rats. Neuroscience Bulletin. htps://doi.org/10.1007/s12264-020-00563-x DOI: https://doi.org/10.1007/s12264-020-00563-x

Zocchi, M., Bartolini, M., Maier, J. A., & Castiglioni, S. (2023). Low extracellular magnesium induces phenotypic and metabolic alterations in C2C12-derived myotubes. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-46543-9 DOI: https://doi.org/10.1038/s41598-023-46543-9

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Publicado

2026-08-25

Cómo citar

Velázquez-Gómez, E., Pérez-Larios, A., & Macías-Carballo , M. (2026). Función del magnesio en la salud mental: revisión de la evidencia sobre la depresión, ansiedad, sueño y cognición. CienciaUAT, 20(2). https://doi.org/10.29059/cienciauat.v20i2.2070

Número

Sección

Revisión actualizada

Categorías

Recibido 2025-11-04
Aceptado 2026-08-19
Publicado 2026-08-25

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