¿Son efectivos los antiinflamatorios no esteroides en el tratamiento del dolor muscular tardío?

Autores/as

  • Ramón Candia-Luján Universidad Autónoma de Chihuahua. Facultad de Ciencias de la Cultura Física, Ciudad Universitaria Chihuahua, Chihuahua, México, C.P. 31009.
  • José Antonio de Paz-Fernández Universidad de León. Instituto de Ciencias Biomédicas (IBIOMED), León, España, 24071.

DOI:

https://doi.org/10.29059/cienciauat.v9i1.630

Palabras clave:

Aspirina, ibuprofeno, naproxeno, prostaglandinas, acciones excéntricas.

Resumen

Los antiinflamatorios no esteroides (AINEs) son uno de los grupos farmacológicos más conocidos y utilizados en la medicina moderna. En el contexto del ejercicio físico son usados por su acción antiinflamatoria y analgésica. El objetivo del presente estudio fue determinar la efectividad de los antiinflamatorios no esteroides en el tratamiento del dolor muscular tardío (DMT), para lo cual se llevó a cabo una revisión durante los meses de octubre a diciembre de 2013 en las bases de datos electrónicas Pubmed, Scopus y SportDiscus, mediante una estrategia de búsqueda de artículos que incluyeran las siguientes palabras clave: antiinflammatory non steroid drugs, NSAIDs, delayed onset muscle soreness y DOMS. Se identificaron 31 estudios, de los cuales 30 eran investigaciones originales y un meta-análisis. Se recuperaron 26 artículos a texto completo y cinco únicamente el resumen. Después de analizar los trabajos se concluye, que si bien los AINEs muestran cierta efectividad real para aliviar el DMT, existe gran diversidad en la dosis, el tiempo de administración utilizado y las características generales de los sujetos en los estudios, por lo que se requieren más investigaciones para establecer su efectividad real.

Citas

Almekinders, L. C. (1999). Anti-inflammatory treatment of muscular injuries in sport. An update of recent studies. Sports Medicine. 28(6): 383-388.

Arendt-Nielsen, L., Weidner, M., Bartholin, D., and Rosetzsky, A. (2007). A double-blind randomized placebo controlled parallel group study evaluating the effects of ibuprofen and glucosamine sulfate on exercise induced muscle soreness. Journal of Musculoskeletal Pain. 15(1): 21-28.

Armstrong, R. B. (1984). Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Medicine and Sciences in Sports and Exercise. 16(6): 529-538.

Barlas, P., Craig, J. A., Robinson, J., Walsh, D. M., Baxter, G. D., and Allen, J. M. (2000). Managing delayed onset muscle soreness: lack of effect of selected oral systemic analgesics. Archives of Physical Medicine and Rehabilitation. 81(7): 966-972.

Baum, K., DTelford, R., and Cunningham, R. B. (2013). Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run. Open Acces Journal of Sports Medicine. 4:109-115.

Bieuzen, F., Bleakley, C. M., and Costello, J. T. (2013). Contrast water therapy and exercise induced muscle damage: A sistematic review and meta-analysis. PLoS ONE. 8(4): 1-15.

Bourgeois, J., MacDougall, D., MacDonald, J., and Tarnopolsky,.M. (1999). Naproxen does not alter indices of muscle damage in resistance-exercise trained men. Medicine and Sciences in Sports and Exercise. 31(1): 4-9.

Bubbico, A. and Kravitz, L. (2010). Eccentric exercise: A comprehensive review of a distinctive training method. IDEA Fitness Journal. 7(9): 50-59.

Byrnes, W. C., Clarkson, P. M., and Katch, F. I. (1985). Muscle soreness following resistance exercise with and without eccentric contractions. / La douleur musculaire apres un exercice de resistance avec et sans contractions excentriques. Research Quarterly for Exercise and Sport. 56 (3): 283-285.

Cannavino, C. R., Abrams, J., Palinkas, L. A., Saglimbeni, A., and Bracker, M. D. (2003). Efficacy of transdermal ketoprofen for delayed onset muscle soreness. Medicine and Sciences in Sports and Exercise. 13(4): 200-208.

Cheung, K., Hume, P., and Maxwell, L. (2003). Delayed onset muscle soreness: treatment strategies and performance factors. Sports Medicine. 33(2): 145-164.

Clissold, S. P. (1986). Aspirin and related derivatives of salicylic acid. Drugs. 32(Suppl. 4): 8-26.

Connolly, D. A., Sayers, S. P., and McHugh, M. P. (2003). Treatment and prevention of delayed onset muscle soreness. Journal of Strength and Conditioning Research. 17(1): 197-208.

Croisier, J. L., Camus, G., Monfils, T., Deby-Dupon, G., Fafchamps, M., Venneman, I. y col. (1996). Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise. Mediators of Inflammation. 5(3): 230-234.

Curtis, D., Fallows, S., Morris, M., and McMakin, C. (2010). The efficacy of frequency specific microcurrent therapy on delayed onset muscle soreness. Journal of Bodywork and Movement Therapies. 14(3): 272-279.

De la O, C. M., Infante, R., Villalba, R., y Erosa, G. (2012). La inflamación y el desarrollo de los antiinflamatorios. Synthesis. (62): 12-15.

De-Vries, H. A. (1966). Quantitative electromiographic investigation of the spasm theory of muscle pain. American Journal of Physical Medicine. 45(3): 119-134.

Donnelly, A. E., McCormick, K., Maughan, R. J., Whiting, P. H., and Clarkson, P. M. (1988). Effects of a non-steroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage. British Journal of Sports Medicine. 22(1): 35-38.

Donnelly, A. E., Maughan, R. J., and Whiting, P. H. (1990). Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage. British Journal of Sports Medicine. 24(3): 191-195.

Dudley, G. A., Czerkawski, J., Meinrod, A., Gillis, G., Baldwin, A., and Scarpone, M. (1997). Efficacy of naproxen sodium for exercise-induced dysfunction muscle injury and soreness. Clinical Journal of Sport Medicine. 7(1): 3-10.

Feucht, C. L. and Patel, D. R. (2010). Analgesics and anti-inflammatory medications in sports: use and abuse. Pediatric Clinics of North America. 57(3): 751-774.

Francis, K. T. (1983). Delayed muscle soreness: a review. Journal of Orthopaedic & Sports Physical Therapy. 5(1): 10-13.

Francis, K. T. and Hoobler, T. (1987). Effects of aspirin on delayed muscle soreness. Journal of Sports Medicine and Physical Fitness. 27(3): 333-337.

Gorski, T. (2011). Use of NSAIDs in triathletes: prevalence, level of awareness and reasons for use. British Journal of Sports Medicine. 45(2): 85-90.

Grossman, J. M., Arnold, B. L., Perrin, D. H., and Kahler, D. M. (1995). Effect of ibuprofen use on delayed onset muscle soreness of the elbow flexors. / Effet de l’Ibuprofene sur la douleur musculaire a apparition differee des muscles flechisseurs du coude. Journal of Sport Rehabilitation. 4(4): 253-263.

Gulick, D. T., Kimura, I. F., Sitler, M., Paolone, A., and Kelly, J. D. (1996). Various treatment techniques on signs and symptoms of delayed onset muscle soreness. Journal of Athletic Training. 31(2): 145-152.

Hasson, S. M., Daniels, J. C., Divine, J. G., Niebuhr, B. R., Richmond, S., Stein, P. G., and Williams, J. H. (1993). Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. / Effet de l’utilisation de l’ibuprofene sur le muscle, inconvenients et performance - etude preliminaire. Medicine and Science in Sports and Exercise. 25(1): 9-17.

Hertel, J. (1997). The role of nonsteroidal anti-inflammatory drugs in the treatment of acute soft tissue injuries. Journal of Athletic Trainng. 32(4): 350-358.

Honceriu, C. and Hagiu, B. A. (2013). Aspects regarding the effect of inflammatory drugs on delayed onset mscle soreness. Sport and Society. 13(1): 3-10.

Hough, T. (1900). Ergographic studies in muscular fatigue and soreness. Journal of Boston Society of Medical Science. 5(3): 81-92.

Houghton, D. and Onambele, G. L. (2012). Can a standard dose of eicosapentaenoic acid (EPA) supplementation reduce the symptoms of delayed onset of muscle soreness? Journal of the International Society of Sports Nutrition. 9(1): 2.

Howatson, G. and van-Someren, K. A. (2008). The Prevention and Treatment of Exercise-Induced Muscle Damage. Sports Medicine. 38(6): 483-503.

Howell, J. N., Conatser, R. R., Chleboun, G. S., Karapondo, D. L., and Chila, A. G. (1998a). The effect of nonsteroidal anti-inflammatory drugs from exercise-induced muscle injury 2. Ibuprofen. Journal of Musculoskeletal Pain. 6(4): 69-83.

Howell, J. N., Conatser, R. R., Chleboun, G. S., Karapondo, D. L., and Chila, A. G. (1998b). The effect of nonsteroidal anti-inflammatorydrugs on recovery from exercise-induced muscle injury 1. Flurbiprofen. Journal of Musculoskeletal Pain. 6(4): 59-68.

Hume, P. A., Cheung, K., Maxwell, L., and Weerapong, P. (2004). DOMS: An overview of treatment strategies. International SportMed Journal. 5(2): 98-118.

Hurley, C. F., Hatfield, D. L., and Riebe, D. A. (2013). The effect of caffeine ingestion on delayed onset muscle soreness. Journal of Strength and Conditionng Research. 27(11): 3101-3109.

Hyldahl, R. D., Keadle, J., Rourier, P. A., Pearl, D., and Clarkson, P. M. (2010). Effects of Ibuprofen Topical Gel on Muscle Soreness. Medicine and Science in Sports and Exercise. 42(3): 614-621.

Krentz, J. R., Quest, B., Farthing, J. P., Quest, D. W., and Chilibeck, P. D.(2008). The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training. Applied Physiology, Nutrition, and Metabolism. 33(3): 470-475.

Kuipers, H., Keizer, H. A., Verstappen, F. T. J., and Costill, D. L. (1985). Influence of a prostaglandin-inhibiting drug on muscle soreness after eccentric work. International Journal of Sports Medicine. 6(6): 336-339.

Lanier, A. B. (2004). Treating DOMS in sport with NSAIDs. International SportMed Journal. 5(2): 129-140.

Lau, W. Y. and Nosaka, K. (2011). Effect of vibration treatment on symptoms associated with eccentric exerciseinduced muscle damage. American Journal of Physical Medicine and Rehabililitation. 90(8): 648-657.

Lecomte, J. M., Lacroix, V. J., and Montgomery, D. L. (1998). A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength. Clinical Journal of Sport Medicine. 8(2): 82-87.

Leeder, J., Gissane, C., van Someren, K., Gregson, W., and Howatson, G. (2012). Cold water immersion and recovery from strenuous exercise: a meta-analysis. British Journal of Sports Medicine. 46(4): 233-240.

Lilly, K. F. (2010). Athletes, NSAID, Coxibs, and the Gastrointestinal Tract. Current Sports Medicine Reports. 9(2): 103-105.

Loram, L. C., Mitchell, D., and Fuller, A. (2005). Rofecoxib and tramadol do not attenuate delayedonset muscle soreness or ischaemic pain in human volunteers. Canadian Journal of Physiology and Pharmacology. 83(12): 1137-1145.

Maroon, J. C., Bost, J. W., and Maroon, A. (2010). Natural anti-inflammatory agents for pain relief. Surgical Neurology International. 1: 80.

Mautner, K. R. (2004). Nonsteroidal anti-inflammatory drugs and sports injuries: Helpful or harmful? Athletic Therapy Today. 9(4): 48-49.

McHugh, M. P., Connolly, D. A., Eston, R. G., and Gleim, G. W. (1999). Exercise-induced muscle damage and potential mechanisms for the repeated bout effect. Sports Medicine. 27(3): 157-170.

McLeay, Y., Barnes, M. J., Mundel, T., Hurst, S. M., Hurst, R. D., and Stannard, S. R. (2012). Effect of New Zealand blueberry consumption on recovery from eccentric exerciseinduced muscle damage. Journal of the International Society of Sports Nutrition. 9(1): 19.

Nelson, N. (2013). Delayed onset muscle soreness: Is massage effective? Journal of Bodywork and Movements Therapies. 17(4): 475-482.

Nieman, D. C., Henson, D. A., Dumke, C. L., Oley, K., McAnulty, S. R., Davis, J. M., Murray, W. J., and Watkins, W. D. (2006). Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. Brain, Behavior, and Immunity. 20(6): 578-584.

O’Grady, M., Hackney, A. C., Schneider, K., Bossen, E., Steinberg, K., Douglas, J. M., Murray, W. J. and Watkins, W. D. (2000). Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle. / Le diclofenac de sodium (Voltarene) attenue les lesions musculaires causees par l’exercice chez l’homme. Medicine and Science in Sports and Exercise. 32(7): 1191-1196.

Paulsen, G., Egner, I. M., Drange, M., Langberg, H., Benestad, H. B., Fjeld, J. G., Hallén, J., and Raastad, T. (2010). A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Scandinavian Journal of Medicine and Science in Sports. 20(1): e195-e207.

Peterson, J. M., Trappe, T. A., Mylona, E., White, F., Lambert, C. P., Evans, W. J., and Pizza, F. X. (2003). Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise. / Effet de l’ibuprophen et de l’acetaminophen sur l’inflammation musculaire suite a un exercice excentrique. Medicine and Science in Sports and Exercise. 35(6): 892-896.

Petrofsky, J., Berk, L., Bains, G., Khowailed, I. A., Hui, T., Granado, M., Laymon, M. and Lee, H. (2013). Moist heat or dry heat for delayed onset muscle soreness. Journal of Clinical Medicine Research. 5(6):416-425.

Rahnama, N., Rahmani-Nia, F., and Ebrahim, K. (2005). The isolated and combined effects of selected physical activity and ibuprofen on delayed onset muscle soreness. Journal of Sports Sciences. 23(8): 843-850.

Rainsford, K. D. (2009). Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 17(6): 275-342.

Riasati, S., Moghadasi, M., Torkfar, A., Shirazinejad, R., and Arin, H. (2010). Aspirin may be an effective treatment for exercise -induced muscle soreness. Brazilian Journal of Biomotricity. 4(3): 206-213.

Rother, M., Seidel, E. J., Clarkson, P. M., Mazgareanu, S., Vierl, U., and Rother, I. (2009). Efficacy of epicutaneous diractin (ketoprofen in transfersome gel) for the treatment of pain related to eccentric muscle contractions. Drug Design, Development and Therapy. 3: 143-149.

Sayers, S. P., and Dannecker, E. A. (2004). How to prevent delayed onset muscle soreness (DOMS) after eccentric exercise. International SportMed Journal. 5(2): 84-97.

Schoenfeld, B. J. (2012). The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage: implications for skeletal muscle development. Sports Medicine. 42(12): 1017-1028.

Semark, A., Noakes, T. D., St. Clair-Gibson, A., and Lambert, M. I. (1999). The effect of a prophylactic dose of flurbiprofen on muscle soreness and sprinting performance in trained subjects. Journal of Sports Sciences. 17(3): 197-203.

Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto,G., Sato, J., Shimomura, N., Kobayashi, H., and Mawatari, K. (2010). Branched-chain amino acid supplementation before squat exercise and delayedonset muscle soreness. International Journal of Sport Nutrition and Exercise Metabolism. 20(3): 236-244.

Stone, M. B., Merrick, M. A., Ingersoll, C. D., and Edwards, J. E. (2002). Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. Clinical Journal of Sport Medicine. 12(6): 373-378.

Stone, M. B., Palmieri, R. M., and Ingersoll, C. D. (2004). The role of non-steroidal anti-inflammatory drugs for the treatment of delayed onset muscle soreness in sport. International SportMed Journal. 5(2): 147-154.

Sultan, A., McQuay, H. J., Moore, R. A., and Derry, S. (2009). Single dose oral flurbiprofen for acute postoperative pain in adults. Cochrane Database of Systematic Review. (3): CD007358.

Tokmakidis, S. P., Kokkinidis, E. A., Smilios, I., and Douda, H. (2003). The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise. Journal of Strength and Conditioning Research. 17(1): 53-59.

Trappe, T. A., White, F., Lambert, C. P., Cesar, D., Hellerstein, M., and Evans, W. J. (2002). Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.American Journal of Physiology Endocrinology and Metabolism. 282(3): E551-E556.

Trombold, J. R., Reinfeld, A. S., Casler, J. R., and Coyle, E. F. (2011). The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. Journal of Strength and Conditioning Research. 25(7): 1782-1788.

Tscholl, P., Alonso, J. M., Dollé, G., Junge, A., and Dvorak, J. (2010). The use of drugs and nutritional supplements in top-level track and field athletes. American Journal of Sports Medicine. 38(1): 133-140.

Warden, S. J. (2010). Prophylactic use of NSAIDs by athletes: a risk/benefit assessment. Physician and Sports Medicine. 38(1): 132-138.

Descargas

Cómo citar

Candia-Luján, R., & de Paz-Fernández, J. A. (2014). ¿Son efectivos los antiinflamatorios no esteroides en el tratamiento del dolor muscular tardío?. CienciaUAT, 9(1), 76-83. https://doi.org/10.29059/cienciauat.v9i1.630

Número

Sección

Medicina y Ciencias de la Salud