Ca2+ transporters and their role in the cancer hallmarks
DOI:
https://doi.org/10.29059/cienciauat.v19i2.1917Keywords:
cancer, calcium transporters, cell proliferation, apoptosis, cell migration and invasionAbstract
Calcium ion (Ca2+) activates crucial signaling pathways involved in different cellular processes, such as proliferation, cell cycle progression, apoptosis and gene expression. Ca2+ signaling depends on various proteins, including channels, pumps, receptors, and binding or storage proteins, which regulate Ca2+ influx, compartmentalization, and concentration for Ca2+ dependent signaling pathways to function properly. This work aimed to analyze evidence regarding the altered expression of Ca2+ transporters in cancer and their contribution to the hallmarks of the disease, mainly sustained cellular proliferation, apoptosis resistance, and activation of migration and invasion. Evidence suggests that overexpression of Ca2+ channels in cancer is associated with increased Ca2+ entry and activation of CaM/CaN/NFAT, Akt or MAPK/ERK signaling pathways, leading to cell proliferation, migration, invasion, and epithelial-mesenchymal transition. On the other hand, the downregulation of Ca2+ pumps or upregulation of mitochondrial channels contributes to apoptosis evasion and enhanced cellular migration. Research on Ca2+ transporters with deregulated expression in cancer may contribute to the identification of potential biomarkers and therapeutic targets for the development of new treatments.
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