Dengue virus: structura, serotypes and molecular epidimilogy
DOI:
https://doi.org/10.29059/cienciauat.v6i3.54Keywords:
Dengue, serotypes, genotypes, endemic regions, genomic variants.Abstract
Dengue fever is one of the most important viral diseases in the world. Dengue virus is transmitted to humans by Aedes aegypti mosquitoes. This virus is the causative agent of dengue fever and severe forms: dengue hemorrhagic fever and Dengue shock syndrome. There are four dengue virus serotypes. The virus spreads in two transmission cycles and considering the source of these infections, is classifi ed as urban and sylvatic. During viral infection and replication, eight proteins are involved in the generation and release of new viruses mature and infectious. In Mexico the first outbreaks of dengue virus appeared in 1941, getting re-emerge in 1978. Recently circulation of all four serotypes of dengue virus in Mexico has been confirmed. Each serotype has different grades of genetic diversity that raise several genotypes. These viral genotypes, contain several alterations in the order of the nucleotidic sequences. The study of the distribution of these genomic variants adds another level of complexity to the study of dengue infection in humans. The article illustrates the importance of Epidemiological of dengue disease and the genotypes that make up the dengue virus serotypes.References
Alcaraz-Estrada, S.L., Yocupicio-Monroy, M. y Del Angel, R.M. (2010). “Insights into dengue virus genome replication”. Future Virology. 5 (5): 575-592.
Amarilla A.A., De Almeida, F.T., Jorge, D.M., Alfonso, H.L., De Castro-Jorge, L.A., Nogueira, N.A., Figueiredo, L.T. y Aquino, V.H. (2009). “Genetic diversity of the E protein of dengue type 3 virus”. Virol J. 6:113.
Carrillo-Valenzo, E., Danis-Lozano, R., Velasco-Hernández, J.X., Sánchez- Burgos, G., Alpuche, C., López, I., Rosales, C., Baronti, C., de Lamballerie X., Holmes, E.C. y Ramos-Castañeda, J. (2010). “Evolution of dengue virus in Mexico is characterized by frequent lineage replacement”. Arch Virol. 155(9): 1401-1412.
Clyde, K., Kyle, J.L. y Harris, E. (2006). “Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis”. J Virol. 80(23): 11418-11431.
Delgado, I., Halstead, S.B. (2000). “Epidemiologic studies on Dengue in Santiago de Cuba, 1997”. Am J Epidemiol. 152(9):793-799.
Dewi, B.E., Takasaki, T., Tajima, S., Sudiro, T.M., Larasati, R.P., Corwin, A.L. y Kurane, I. (2009). “Genotypic and phenotypic characteristic of DENV-3 isolated from patients with different disease severities in Indonesia”. Dengue Bulletin. 33: 45-58.
Faheem, M., Raheel, U., Riaz, M.N., Kanwal, N., Javed, F., us Sahar Sadaf Zaidi, N. y Qadri, I. (2011). “A molecular evaluation of dengue virus pathogenesis and its latest vaccine strategies”. Mol Biol Rep. 38(6): 3731-3740.
Gardella-García, C.E., Pérez-Ramírez, G., Navarrete-Espinosa, J., Cisneros, A., Jiménez-Rojas, F., Ramírez-Palacios, L.R., Rosado-León R., Camacho-Nuez, M. y Muñoz Mde, L. (2008). “Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico”. BMC Microbiol. 8:117 Pp.
Gubler, J.D. (1998). “Dengue and Dengue Hemorrhagic Fever”. Clinical Microbiology Reviews. 3: 480-496.
Guzmán, M.G., Halstead, S.B., Artsob, H., Buchy, P., Farrar, J., Gubler, D.J., Hunsperger, E., Kroeger, A., Margolis, H.S., Martínez, E., Nathan, M.B., Pelegrino, J.L., Simmons, C., Yoksan, S. y Peeling, R.W. (2010). “Dengue: a continuing global threat”. Nat Rev Microbiol. 8(12 suppls 12): 7-16.
Guzmán, M.G., Kouri, G., Valdés, L., Bravo, J., Álvarez, M., Vazqués, S., Holmes, E.C. y Twiddy, S.S. (2003). “The origin, emergence and evolutionary genetics of dengue virus”. Infect Genet Evol.; 3(1): 19-28.
King, C.C., Chao, D.Y., Chien, L.J., Chang, G.J., Lin, T.H., Wu, Y.C. y Huang, J.H. (2008). “Comparative analysis of full genomic sequences among different genotypes of dengue virus type “3. Virol J. 5:63 Pp.
Kuhn, R.J., Zhang, W., Rossmann, M.G., Pletnev, S.V., Corver, J., Lenches, E., Jones, C.T., Mukhopadhyay, S., Chipman, P.R., Strauss, E.G., Baker, T.S. y Strauss, J.H. (2002). “Structure of dengue virus: implications for flavivirus organization, maturation, and fusion”. Cell. 108(5): 717-725.
Lambrechts, L., Chevillon, C., Albright, R.G., Thaisomboonsuk, B., Richardson, J.H., Jarman, R.G. y Scott, T.W.(2009). “Genetic specifi city and potential for local adaptation between dengue viruses and mosquito vectors”. BMC Evol Biol. 9: 160 Pp.
Martina, B.E., Koraka, P. y Osterhaus, A.D. (2009). “Dengue virus pathogenesis: an integrated view”. Clin Microbiol Rev. 4: 564-581.
Narro-Robles, J. y Gómez-Dantés, H. (1995). “Dengue in Mexico: a priority problem of public health”. Salud Pública Mex. 37(suppl s): 12-20.
National Center Biotechnology Information (2012). Secuencias genómicas de dengue en México. [En línea]. Disponible en http://www.ncbi.nlm.nih.gov/genomes/VirusVariation/Database/nphselect.cgi. Fecha de consulta: 03 Junio de 2012.
Nukui, Y., Tajima, S., Kotaki, A., Ito, M., Takasaki, T., Koike, K. y Kurane, I. (2006). “Novel dengue virus type 1 from travelers to Yap State, Micronesia”. Emerg Infect Dis. 2: 343-346.
Pérez-Ramírez, G., Díaz-Badillo, A., Camacho-Nuez, M., Cisneros, A. y Muñoz Mde, L. (2009). “Multiple recombinants in two dengue virus, serotype-2 isolates from patients from Oaxaca, México”. BMC Microbiol. 9: 260 Pp.
Quintero, D., Osorio, J. y Martínez, M.(2010). “Competencia vectorial: consideraciones entomológicas y su influencia sobre la epidemiología del Dengue”. Iatreia. 23(2): 146-156.
Ramos, G.E. (2010). “La fiebre por dengue en México: un problema creciente de salud pública”, en Hypatia. 33. [En línea]. Disponible en: http://hypatia.morelos.gob.mx/. Fecha de consulta: 26 Mayo de 2012.
Rodenhuis-Zybert, I.A., Wilschut, J. y Smit, J.M. (2010). “Dengue virus life cycle: viral and host factors modulating infectivity”. Cell Mol Life Sci. 67(16): 2773-2786.
Secretaría de Salud (2012a). Boletín semanal de vigilancia epidemiológica. [En línea]. Disponible en: http://www.dgepi.salud.gob.mx/denguepano/ PANORAMAS_2012/Pano_dengue_ sem20_2012.pdf. Fecha de consulta: 20 Mayo de 2012.
Secretaría de Salud (2012b). Serotipos circulantes en México. [En línea]. Disponible en: http://www.dgepi. salud.gob.mx/denguepano/ PANORAMAS_2012/Pano_dengue_ sem18_2012.pdf. Fecha de consulta: 30 Abril de 2012.
Shu P.Y. y Huang JH. (2004). “Current advances in dengue diagnosis”. Clin Diagn Lab Immunol. 11(4): 642-50.
Smith, K.M., Nanda, K., Spears, C.J., Ribeiro, M., Vancini, R., Piper, A., Thomas, G.S., Thomas, M.E., Brown, D.T. y Hernández, R.(2011). “Structural mutants of dengue virus 2 transmembrane domains exhibit hostrange phenotype”. Virol J. 8: 289 Pp.
Tomlinson, S.M., Malmstrom, R.D. y Watowich, S.J. (2009). “New approaches to structure-based discovery of dengue protease inhibitors”. Infect Disord Drug Targets. 9(3): 327-343.
Vasilakis, N., Cardosa, J., Hanley, K.A., Holmes, E.C. y Weaver, S.C. (2011). “Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health”. Nat Rev Microbiol. 9(7): 532-541.
Welsch, S., Miller, S., Romero-Brey, I., Merz, A., Bleck, C.K., Walther, P., Fuller, S.D., Antony, C., Krijnse-Locker, J. y Bartenschlager, R. (2009). “Composition and three-dimensional architecture of the dengue virus replication and assembly sites”. Cell Host Microbe. 5: 365-375.
Whitehead, S.S., Blaney, J.E., Durbin, A.P. y Murphy, B.R. (2007). “Prospects for dengue virus vaccine”. Nat Rev Microbiol. 5(4): 518-528.
