Bioactive peptides derived from bean seeds (Phaseolus vulgaris L.)
DOI:
https://doi.org/10.29059/cienciauat.v19i1.1872Keywords:
beans, biopeptides, biological activity, protein hydrolysatesAbstract
Various compounds of plant origin can contribute to the control and prevention of diseases considered a public health problem, including chronic-degenerative diseases. Plant-based proteins are an excellent alternative compared to those of animal origin due to their lower carbon footprint, and they are also an excellent source of peptides that have different biological activities. The aim of this work was to analyze the research progress on the protein hydrolysates/peptides that are encrypted in the storage proteins of the seeds of the common bean (Phaseolus vulgaris L.). Studies have focused on its production process (enzymatic hydrolysis, microbial fermentation, and met-hod synthetic), purification and identification and evidence of its functional activities such as antioxidant, antihypertensive, antidiabetic among others. The research that has been carried out and that is concentrated in this document aim that in the future protein hydrolysates derived from the bean that have demonstrated biological activity (in vitro and in vivo) can offer nutraceutical and therapeutic potential in addition to their incorporation into the development of functional foods.
References
Acquah, C., Dzuvor, C. K. O., Tosh, S., & Agyei, D. (2022). Anti-diabetic effects of bioactive peptides: recent advances and clinical implications. Critical reviews in food science and nutrition, 62(8), 2158-2171. https://doi.org/10.1080/10408398.2020.1851168
ADA, American Diabetes Association (2020). 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020. Diabetes Care, 43(Supplement_1), S98-S110. https://doi.org/10.2337/dc20-S009
ADA, American Diabetes Association (2021). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care, 44(Supplement_1), S15-S33. https://doi.org/10.2337/dc21-S002
Adamson, N. J. & Reynolds, E. C. (1996). Characterization of casein phosphopeptides prepared using alcalase: Determination of enzyme specificity. Enzyme and microbial technology, 19(3), 202–207. https://doi.org/10.1016/0141-0229(95)00232-4
Aguilar, J. G., dos, S., Granato-Cason, V., & de-Castro, R. J. S. (2019). Improving antioxidant activity of black bean protein by hydrolysis with protease combinations. International Journal of food science & technology, 54(1), 34-41. https://doi.org/10.1111/ijfs.13898
Ahamad, J., Ali, F., Sayed, M. A., Ahmad, J., & Nollet, L. M. L. (2022). Basic Principles and Fundamental Aspects of Mass Spectrometry. In L. Nollet & R. Winkler (Eds.), Mass spectrometry in food analysis (pp. 3-17). CRC Press. https://doi.org/10.1201/9781003091226-2
Akbarian, M., Khani, A., Eghbalpour, S., & Uversky, V. N. (2022). Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action. International Journal of molecular sciences, 23(3), 1445–1474. https://doi.org/10.3390/ijms23031445
Akıllıoğlu, H. G. & Karakaya, S. (2009). Effects of heat treatment and in vitro digestion on the Angiotensin converting enzyme inhibitory activity of some legume species. European food research and technology, 229(6), 915-921. https://doi.org/10.1007/s00217-009-1133-x
Alidoost, S., Maleki, M., & Pourasghari, H. (2021). Identifying drivers and factors affecting behavioral risk factors of noncommunicable diseases: A scoping review. Journal of education and health promotion, 10, 398-406. https://doi.org/10.4103/jehp.jehp_1379_20
Al-Ruwaih, N., Ahmed, J., Mulla, M. F., & Arfat, Y. A. (2019). High-pressure assisted enzymatic proteolysis of kidney beans protein isolates and characterization of hydrolysates by functional, structural, rheological and antioxidant properties. LWT, 100, 231-236. https://doi.org/10.1016/j.lwt.2018.10.074
Antony, P. & Vijayan, R. (2021). Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review. International journal of molecular sciences, 22(16), 9059. https://doi.org/10.3390/ijms22169059
Aondona, M. M., Ikya, J. K., Ukeyima, M. T., Gborigo, T. J. A., Aluko, R. E., & Girgih, A. T. (2021). In vitro antioxidant and antihypertensive properties of sesame seed enzymatic protein hydrolysate and ultrafiltration peptide fractions. Journal of food biochemistry, 45(1), e13587–e13599. https://doi.org/10.1111/jfbc.13587
Ariza-Ortega, T. D. J., Zenón-Briones, E. Y., Castrejón-Flores, J. L., Yáñez-Fernández, J., Gómez-Gómez, Y. D. L. M., & Oliver-Salvador, M. D. C. (2014). Angiotensin-I-converting enzyme inhibitory, antimicrobial, and antioxidant effect of bioactive peptides obtained from different varieties of common beans (Phaseolus vulgaris L.) with in vivo antihypertensive activity in spontaneously hypertensive rats. European food research and technology, 239(5). https://doi.org/10.1007/s00217-014-2271-3
Babini, E., Tagliazucchi, D., Martini, S., Dei-Più, L., & Gianotti, A. (2017). LC-ESI-QTOF-MS identification of novel antioxidant peptides obtained by enzymatic and microbial hydrolysis of vegetable proteins. Food chemistry, 228, 186–196. https://doi.org/10.1016/j.foodchem.2017.01.143
Baker, M. T., Lu, P., Parrella, J. A., & Leggette, H. R. (2022). Consumer Acceptance toward Functional Foods: A Scoping Review. International Journal of environmental research and public health, 19(3), 1217. https://doi.org/10.3390/ijerph19031217
Balasubramaniam, V. M., Martínez-Monteagudo, S. I., & Gupta, R. (2015). Principles and Application of High Pressure–Based Technologies in the Food Industry. Annual review of food science and technology, 6(1), 435-462. https://doi.org/10.1146/annurev-food-022814-015539
Barati, M., Javanmardi, F., Mousavi-Jazayeri, S. M. H., Jabbari, M., Rahmani, J., Barati, F., Nickho, H., Davoodi, S. H., Roshanravan, N., & Mousavi-Khaneghah, A. (2020). Techniques, perspectives, and challenges of bioactive peptide generation: A comprehensive systematic review. Comprehensive Reviews in Food Science and Food Safety, 19(4), 1488-1520. https://doi.org/10.1111/1541-4337.12578
Barredo-Vacchelli, G. R., Giudicessi, S. L., Martínez-Ceron, M. C., Cascone, O., & Camperi, S. A. (2021). Peptide Affinity Chromatography Applied to Therapeutic Antibodies Purification. International journal of peptide research and therapeutics, 27(4), 2905–2921. https://doi.org/10.1007/s10989-021-10299-5
Bessada, S. M. F., Barreira, J. C. M., & Oliveira, M. B. P. P. (2019). Pulses and food security: Dietary protein, digestibility, bioactive and functional properties. Trends in food science & technology, 93, 53-68. https://doi.org/10.1016/j.tifs.2019.08.022
Betancur-Ancona, D., Sosa-Espinoza, T., Ruiz-Ruiz, J., Segura-Campos, M., & Chel-Guerrero, L. (2014). Enzymatic hydrolysis of hard-to-cook bean (Phaseolus vulgaris L.) protein concentrates and its effects on biological and functional properties. International journal of food science and technology, 49(1), 2-8. https://doi.org/10.1111/ijfs.12267
Bhandari, D., Rafiq, S., Gat, Y., Gat, P., Waghmare, R., & Kumar, V. (2020). A Review on Bioactive Peptides: Physiological Functions, Bioavailability and Safety. International journal of peptide research and therapeutics, 26(1), 139-150. https://doi.org/10.1007/s10989-019-09823-5
Bitocchi, E., Nanni, L., Bellucci, E., Rossi, M., Giardini, A., Zeuli, P. S., Logozzo, G., Stougaard, J., McClean, P., Attene, G., & Papa, R. (2012). Mesoamerican origin of the common bean (Phaseolus vulgaris L.) is revealed by sequence data. Proceedings of the national academy of sciences, 109(14), E788-E796. https://doi.org/10.1073/pnas.1108973109
Carrasco-Castilla, J., Hernández-Álvarez, A. J., Jiménez-Martínez, C., Jacinto-Hernández, C., Alaiz, M., Girón-Calle, J., Vioque, J., & Dávila-Ortiz, G. (2012). Antioxidant and metal chelating activities of peptide fractions from phaseolin and bean protein hydrolysates. Food chemistry, 135(3), 1789-1795. https://doi.org/10.1016/j.foodchem.2012.06.016
Castañeda-Pérez, E., Jiménez-Morales, K., Quintal-Novelo, C., Moo-Puc, R., Chel-Guerrero, L., & Betancur-Ancona, D. (2019). Enzymatic protein hydrolysates and ultrafiltered peptide fractions from Cowpea Vigna unguiculata L bean with in vitro antidiabetic potential. Journal of the iranian chemical society, 16(8), 1773-1781. https://doi.org/10.1007/s13738-019-01651-0
Chel-Guerrero, L., Domínguez-Magaña, M., Martínez-Ayala, A., Dávila-Ortiz, G., & Betancur-Ancona, D. (2012). Lima Bean (<i>Phaseolus lunatus</i>) Protein Hydrolysates with ACE-I Inhibitory Activity. Food and nutrition sciences, 03(04), 511-521. https://doi.org/10.4236/fns.2012.34072
Choudhary, N., Anjali, Gupta, M., Shafi, S., Jan, S., Hamid-Mir, A., Singh, B., & Rouf-Mir, R. (2022). Molecular diversity and nutriment studies of common bean (Phaseolus vulgaris L.) from the two hot-spots of Western Himalayas of Jammu and Kashmir. Crop & pasture science, 73(3), 249-262. https://doi.org/10.1071/CP21347
Cruz-Casas, D. E., Aguilar, C. N., Ascacio-Valdés, J. A., Rodríguez-Herrera, R., Chávez-González, M. L., & Flores-Gallegos, A. C. (2021). Enzymatic hydrolysis and microbial fermentation: The most favorable biotechnological methods for the release of bioactive peptides. Food chemistry: molecular sciences, 3, 100047-100058. https://doi.org/10.1016/j.fochms.2021.100047
Das, S. & Hati, S. (2022). Food derived ACE inhibitory peptides: science to application. In D. Bagchi & S. E. Ohia (Eds.), Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health (pp. 39-54). Elsevier. https://doi.org/10.1016/B978-0-12-821232-5.00006-9
De-Souza-Rocha, T., Hernandez, L. M. R., Mojica, L., Johnson, M. H., Chang, Y. K., & González-de-Mejía, E. (2015). Germination of Phaseolus vulgaris and alcalase hydrolysis of its proteins produced bioactive peptides capable of improving markers related to type-2 diabetes in vitro. Food research international, 76(P1), 150-159. https://doi.org/10.1016/j.foodres.2015.04.041
De-Vuyst, L. & Leroy, F. (2007). Bacteriocins from Lactic Acid Bacteria: Production, Purification, and Food Applications. Microbial physiology, 13(4), 194-199. https://doi.org/10.1159/000104752
De-Fátima-Garcia, B., de-Barros, M., & de-Souza-Rocha, T. (2021). Bioactive peptides from beans with the potential to decrease the risk of developing noncommunicable chronic diseases. Critical reviews in food science and nutrition, 61(12), 2003-2021. https://doi.org/10.1080/10408398.2020.1768047
Evangelho, J. A., Vanier, N. L., Pinto, V. Z., Berrios, J. J. D., Dias, A. R. G., & Zavareze, E. R. (2017). Black bean (Phaseolus vulgaris. L.) protein hydrolysates: Physicochemical and functional properties. Food chemistry, 214, 460-467. https://doi.org/10.1016/j.foodchem.2016.07.046
FAO, Food and Agriculture Organization of the United Nations (2022). FAOSTAT. CROPS. [En línea]. Disponible en: http://www.fao.org/faostat/en/#data/QC/visualize. Fecha de consulta: 22 de enero de 2024.
Freytag, G. F. & Debouck, D. G. (2002). Taxonomy, distribution, and ecology of the genus Phaseolus (Leguminosae-Papilionoideae) in North America, Mexico and Central America. [En línea]. Disponible en: https://api.semanticscholar.org/CorpusID:130456466. Fecha de consulta: 22 de enero de 2024.
Garcia-Mora, P., Frias, J., Peñas, E., Zieliński, H., Giménez-Bastida, J. A., Wiczkowski, W., Zielińska, D., & Martínez-Villaluenga, C. (2015). Simultaneous release of peptides and phenolics with antioxidant, ACE-inhibitory and anti-inflammatory activities from pinto bean (Phaseolus vulgaris L. var. pinto) proteins by subtilisins. Journal of functional foods, 18, 319-332. https://doi.org/10.1016/j.jff.2015.07.010
Gharibzahedi, S. M. T., Smith, B., & Altintas, Z. (2024). Bioactive and health-promoting properties of enzymatic hydrolysates of legume proteins: a review. Critical reviews in food science and nutrition, 64(9), 2548-2578
Goldstein, N. & Reifen, R. (2022). The potential of legume-derived proteins in the food industry. Grain & oil science and technology, 5(4), 167-178. https://doi.org/10.1016/j.gaost.2022.06.002
Gomes, M. J. C., Lima, S. L. S., Alves, N. E. G., Assis, A., Moreira, M. E. C., Toledo, R. C. L., Rosa, C. O. B., Teixeira, O. R., Bassinello, P. Z., de-Mejía, E. G., & Martino, H. S. D. (2020). Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet. Nutrition, metabolism and cardiovascular diseases, 30(1), 141-150. https://doi.org/10.1016/j.numecd.2019.07.020
Granato, D., Barba, F. J., Bursać-Kovačević, D., Lorenzo, J. M., Cruz, A. G., & Putnik, P. (2020). Functional Foods: Product Development, Technological Trends, Efficacy Testing, and Safety. Annual review of food science and technology, 11(1), 93-118. https://doi.org/10.1146/annurev-food-032519-051708
Grdeń, P. & Jakubczyk, A. (2023). Health benefits of legume seeds. Journal of the science of food and agriculture, 103(11), 5213-5220. https://doi.org/10.1002/jsfa.12585
Gulcin, İ. (2020). Antioxidants and antioxidant methods: an updated overview. Archives of toxicology, 94(3), 651-715. https://doi.org/10.1007/s00204-020-02689-3
Hernández-Corroto, E., Plaza, M., Marina, M. L., & García, M. C. (2020). Sustainable extraction of proteins and bioactive substances from pomegranate peel (Punica granatum L.) using pressurized liquids and deep eutectic solvents. Innovative food science & emerging technologies, 60, 102314–102324. https://doi.org/10.1016/j.ifset.2020.102314
Herrera-Hernández, I. M., Sánchez, E., Ramírez-Estrada, C. A., Anchondo-Páez, J. C., & Pérez-Álvarez, S. (2023). Supply of essential and nonessential amino acids, proteins, antioxidants, iron and zinc from the main varieties of beans consumed in Mexico and their potential for biofortification. Notulae scientia biologicae, 15(4), 11733. https://doi.org/10.55779/nsb15411733
Hu, K., Huang, H., Li, H., Wei, Y., & Yao, C. (2023). Legume-Derived Bioactive Peptides in Type 2 Diabetes: Opportunities and Challenges. Nutrients, 15(5), 1096. https://doi.org/10.3390/nu15051096
IDF, International Diabetes Federation (2021). IDF Diabetes Atlas (Tenth edition). International Diabetes Federation. [En línea]. Disponible en: https://diabetesatlas.org/atlas/tenth-edition/. Fecha de consulta: 22 de enero de 2024.
Jakubczyk, A., Karaś, M., Złotek, U., & Szymanowska, U. (2017). Identification of potential inhibitory peptides of enzymes involved in the metabolic syndrome obtained by simulated gastrointestinal digestion of fermented bean (Phaseolus vulgaris L.) seeds. Food research international, 100, 489-496. https://doi.org/10.1016/j.foodres.2017.07.046
Jogi, N., Yathisha, U. G., Bhat, I., & Mamatha, B. S. (2022). Antihypertensive activity of orally consumed ACE-I inhibitory peptides. Critical reviews in food science and nutrition, 62(32), 8986-8999. https://doi.org/10.1080/10408398.2021.1938508
Karami, Z. & Duangmal, K. (2023). Health Promoting and Functional Activities of Peptides from Vigna Bean and Common Bean Hydrolysates: Process to Increase Activities and Challenges. Food reviews international, 39(9), 6537-6567. https://doi.org/10.1080/87559129.2022.2122988
Kaur, N. (2018). Solid-phase synthesis of sulfur containing heterocycles. Journal of sulfur chemistry, 39(5), 544–577. https://doi.org/10.1080/17415993.2018.1457673
Kent, S. B. H. (2019). Novel protein science enabled by total chemical synthesis. Protein science, 28(2), 313–328. https://doi.org/10.1002/pro.3533
Li, T., Shi, C., Zhou, C., Sun, X., Ang, Y., Dong, X., Huang, M., & Zhou, G. (2020). Purification and characterization of novel antioxidant peptides from duck breast protein hydrolysates. LWT, 125, 109215-109227. https://doi.org/10.1016/j.lwt.2020.109215
Lin, X., Xu, Y., Pan, X., Xu, J., Ding, Y., Sun, X., Song, X., Ren, Y., & Shan, P. F. (2020). Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific reports, 10(1), 14790. https://doi.org/10.1038/s41598-020-71908-9
Lorenzo, J. M., Munekata, P. E. S., Gómez, B., Barba, F. J., Mora, L., Pérez-Santaescolástica, C., & Toldrá, F. (2018). Bioactive peptides as natural antioxidants in food products – A review. Trends in food science & technology, 79, 136-147. https://doi.org/10.1016/j.tifs.2018.07.003
Luna-Vital, D. A., González-de-Mejía, E., Dia, V. P., & Loarca-Piña, G. (2014). Peptides in common bean fractions inhibit human colorectal cancer cells. Food chemistry, 157, 347-355. https://doi.org/10.1016/j.foodchem.2014.02.050
Maestri, E., Pavlicevic, M., Montorsi, M., & Marmiroli, N. (2019). Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability. Comprehensive reviews in food science and food safety, 18(1), 3-30. https://doi.org/10.1111/1541-4337.12402
Marciniak, A., Suwal, S., Naderi, N., Pouliot, Y., & Doyen, A. (2018). Enhancing enzymatic hydrolysis of food proteins and production of bioactive peptides using high hydrostatic pressure technology. Trends in food science & technology, 80, 187–198. https://doi.org/10.1016/j.tifs.2018.08.013
McClements, D. J. & Grossmann, L. (2021). The science of plant-based foods: Constructing next-generation meat, fish, milk, and egg analogs. Comprehensive reviews in food science and food safety, 20(4), 4049-4100. https://doi.org/10.1111/1541-4337.12771
Miklas, P. N., Kelly, J. D., & Cichy, K. A. (2022). Dry Bean Breeding and Production Technologies. In M. Siddiq & M. A. Uebersax (Eds.), Dry Beans and Pulses (pp. 29-56). Wiley. https://doi.org/10.1002/9781119776802.ch2
Mojica, L., Chen, K., & de-Mejía, E. G. (2015). Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin-Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase-IV. Journal of food science, 80(1). https://doi.org/10.1111/1750-3841.12726
Mojica, L. & de-Mejía, E. G. (2015). Characterization and Comparison of Protein and Peptide Profiles and their Biological Activities of Improved Common Bean Cultivars (Phaseolus vulgaris L.) from Mexico and Brazil. Plant foods for human nutrition, 70(2), 105-112. https://doi.org/10.1007/s11130-015-0477-6
Mojica, L. & de-Mejía, E. G. (2016). Optimization of enzymatic production of antidiabetic peptides from black bean (Phaseolus vulgaris L.) proteins, their characterization and biological potential. Food and function, 7(2). https://doi.org/10.1039/c5fo01204j
Mojica, L., de-Mejia, E. G., Menjivar, M., & Granados-Silvestre, M. Á. (2016). Antidiabetic Effect of Black Bean Peptides through Reduction of Glucose Absorption and Modulation of SGLT1, GLUT2 and DPP-IV in in vitro and in vivo Models. The FASEB journal, 30(S1). https://doi.org/10.1096/fasebj.30.1_supplement.125.6
Mojica, L., Luna-Vital, D. A., & González-de-Mejía, E. (2017). Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress. Journal of the science of food and agriculture, 97(8), 2401-2410. https://doi.org/10.1002/jsfa.8053
Montoya, C. A., Lallès, J. P., Beebe, S., & Leterme, P. (2010). Phaseolin diversity as a possible strategy to improve the nutritional value of common beans (Phaseolus vulgaris). Food research international, 43(2), 443–449. https://doi.org/10.1016/j.foodres.2009.09.040
Mora, L. & Toldrá, F. (2021). Methodologies for peptidomics: Identification and quantification. In F. Toldrá & J. Wu (Eds.), Biologically Active Peptides (pp. 87-102). Elsevier. https://doi.org/10.1016/B978-0-12-821389-6.00010-8
Moreno-Valdespino, C. A., Luna-Vital, D., Camacho-Ruiz, R. M., & Mojica, L. (2020). Bioactive proteins and phytochemicals from legumes: Mechanisms of action preventing obesity and type-2 diabetes. Food research international, 130, 108905. https://doi.org/10.1016/j.foodres.2019.108905
Mourtas, S., Athanasopoulos, V., Gatos, D., & Barlos, K. (2023). Solid-Phase Synthesis of 2-Benzothi azolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides. Molecules, 28(14), 5412–5431. https://doi.org/10.3390/molecules28145412
Mudgil, P., Baby, B., Ngoh, Y. Y., Kamal, H., Vijayan, R., Gan, C. Y., & Maqsood, S. (2019). Molecular binding mechanism and identification of novel antihypertensive and anti-inflammatory bioactive peptides from camel milk protein hydrolysates. LWT, 112, 108193-108204. https://doi.org/10.1016/j.lwt.2019.05.091
Mullins, A. P. & Arjmandi, B. H. (2021). Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases. Nutrients, 13(2), 519. https://doi.org/10.3390/nu13020519
Naeem, M., Malik, M. I., Umar, T., Ashraf, S., & Ahmad, A. (2022). A Comprehensive Review About Bioactive Peptides: Sources to Future Perspective. International journal of peptide research and therapeutics, 28(6), 155-175. https://doi.org/10.1007/s10989-022-10465-3
Ngoh, Y. Y. & Gan, C. Y. (2016). Enzyme-assisted extraction and identification of antioxidative and a-amylase inhibitory peptides from Pinto beans (Phaseolus vulgaris cv. Pinto). Food chemistry, 190, 331-337. https://doi.org/10.1016/j.foodchem.2015.05.120
Ngoh, Y. Y. & Gan, C. Y. (2018). Identification of Pinto bean peptides with inhibitory effects on a-amylase and angiotensin converting enzyme (ACE) activities using an integrated bioinformatics-assisted approach. Food chemistry, 267, 124-131. https://doi.org/10.1016/j.foodchem.2017.04.166
Obiro, W. C., Zhang, T., & Jiang, B. (2008). The nutraceutical role of the Phaseolus vulgaris a-amylase inhibitor. British journal of nutrition, 100(1), 1-12. https://doi.org/10.1017/S0007114508879135
Ohara, A., Cason, V. G., Nishide, T. G., Miranda-de-Matos, F., & de-Castro, R. J. S. (2021). Improving the antioxidant and antidiabetic properties of common bean proteins by enzymatic hydrolysis using a blend of proteases. Biocatalysis and biotransformation, 39(2), 100-108. https://doi.org/10.1080/10242422.2020.1789114
Olagunju, A. I., Omoba, O. S., Enujiugha, V. N., Alashi, A. M., & Aluko, R. E. (2018). Pigeon pea enzymatic protein hydrolysates and ultrafiltration peptide fractions as potential sources of antioxidant peptides: An in vitro study. LWT, 97, 269–278. https://doi.org/10.1016/j.lwt.2018.07.003
Osborne, T. B. (1924). The vegetable proteins. Longmans, Green and Company.
Oseguera-Toledo, M. E., Gonzalez-de-Mejia, E., & Amaya-Llano, S. L. (2015). Hard-to-cook bean (Phaseolus vulgaris L.) proteins hydrolyzed by alcalase and bromelain produced bioactive peptide fractions that inhibit targets of type-2 diabetes and oxidative stress. Food research international, 76, 839-851. https://doi.org/10.1016/j.foodres.2015.07.046
Ozawa, A., Cai, Y., & Lindberg, I. (2007). Production of bioactive peptides in an in vitro system. Analytical biochemistry, 366(2), 182–189. https://doi.org/10.1016/j.ab.2007.04.020
Peighambardoust, S. H., Karami, Z., Pateiro, M., & Lorenzo, J. M. (2021). A Review on Health-Promoting, Biological, and Functional Aspects of Bioactive Peptides in Food Applications. Biomolecules, 11(5), 631-651. https://doi.org/10.3390/biom11050631
Piovesana, S., Capriotti, A. L., Cavaliere, C., La Bar-bera, G., Montone, C. M., Zenezini Chiozzi, R., & Laganà, A. (2018). Recent trends and analytical challenges in plant bioactive peptide separation, identification and validation. Analytical and Bioanalytical Chemistry, 410(15), 3425–3444. https://doi.org/10.1007/s00216-018-0852-x
Piovesana, S., Capriotti, A. L., Cavaliere, C., La-Barbera, G., Montone, C. M., Zenezini-Chiozzi, R., & Laganà, A. (2019). Sensitive untargeted identification of short hydrophilic peptides by high performance liquid chromatography on porous graphitic carbon coupled to high resolution mass spectrometry. Journal of chromatography A, 1590, 73–79. https://doi.org/10.1016/j.chroma.2018.12.066
Polanco-Lugo, E., Dávila-Ortiz, G., Betancur-Ancona, D. A., & Chel-Guerrero, L. A. (2014). Effects of sequential enzymatic hydrolysis on structural, bioactive and functional properties of Phaseolus lunatus protein isolate. Food science and technology, 34(3), 441-448. https://doi.org/10.1590/1678-457x.6349
Porch, T., Beaver, J., Debouck, D., Jackson, S., Kelly, J., & Dempewolf, H. (2013). Use of Wild Relatives and Closely Related Species to Adapt Common Bean to Climate Change. Agronomy, 3(2), 433-461. https://doi.org/10.3390/agronomy3020433
Rahmi, A. & Arcot, J. (2023). In Vitro Assessment Methods for Antidiabetic Peptides from Legumes: A Review. Foods, 12(3), 631. https://doi.org/10.3390/foods12030631
Rogalinski, T., Herrmann, S., & Brunner, G. (2005). Production of amino acids from bovine serum albumin by continuous sub-critical water hydrolysis. The journal of supercritical fluids, 36(1), 49–58. https://doi.org/10.1016/j.supflu.2005.03.001
Roy, M., Sarker, A., Azad, M. A. K., Shaheb, M. R., & Hoque, M. M. (2020). Evaluation of antioxidant and antimicrobial properties of dark red kidney bean (Phaseolus vulgaris) protein hydrolysates. Journal of food measurement and characterization, 14(1), 303-313. https://doi.org/10.1007/s11694-019-00292-4
Rui, X., Boye, J. I., Simpson, B. K., & Prasher, S. O. (2012). Angiotensin I-converting enzyme inhibitory properties of Phaseolus vulgaris bean hydrolysates: Effects of different thermal and enzymatic digestion treatments. Food research international, 49(2), 739-746. https://doi.org/10.1016/j.foodres.2012.09.025
Rui, X., Boye, J. I., Simpson, B. K., & Prasher, S. O. (2013). Purification and characterization of angiotensin I-converting enzyme inhibitory peptides of small red bean (Phaseolus vulgaris) hydrolysates. Journal of functional foods, 5(3), 1116-1124. https://doi.org/10.1016/j.jff.2013.03.008
Ruiz-Ruiz, J., Davila-Ortiz, G., Chel-Guerrero, L., & Betancur-Ancona, D. (2013). Angiotensin i-con-verting enzyme inhibitory and antioxidant peptide fractions from hard-to-cook bean enzymatic hydrolysates. Journal of food biochemistry, 37(1), 26-35. https://doi.org/10.1111/j.1745-4514.2011.00594.x
Saad, A. M., Osman, A. O. M., Mohamed, A. S., & Ramadan, M. F. (2020). Enzymatic Hydrolysis of Phaseolus vulgaris Protein Isolate: Characterization of Hydrolysates and Effect on the Quality of Minced Beef During Cold Storage. International journal of peptide research and therapeutics, 26(1), 567–577. https://doi.org/10.1007/s10989-019-09863-x
Sánchez, A. & Vázquez, A. (2017). Bioactive peptides: A review. Food quality and safety, 1(1), 29–46. https://doi.org/10.1093/fqs/fyx006
Shabir, I., Dash, K. K., Dar, A. H., Pandey, V. K., Fayaz, U., Srivastava, S., & Nisha, R. (2023). Carbon footprints evaluation for sustainable food processing system development: A comprehensive review. Future Foods, 7, 100215. https://doi.org/10.1016/j.fufo.2023.100215
Siddiq, M., Uebersax, M. A., & Siddiq, F. (2022). Global Production, Trade, Processing and Nutritional Profile of Dry Beans and Other Pulses. In M. Siddiq & M. A. Uebersax (Eds.), Dry Beans and Pulses (pp. 1–28). Wiley. https://doi.org/10.1002/9781119776802.ch1
Su, L., Shi, Y., Yan, M., Xi, Y., & Su, X. (2015). Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway. Acta pharmacologica sinica, 36(12), 1514–1519. https://doi.org/10.1038/aps.2015.80
Su, Y., Chen, S., Liu, S., Wang, Y., Chen, X., Xu, M., Cai, S., Pan, N., Qiao, K., Chen, B., Yang, S., & Liu, Z. (2023). Affinity Purification and Molecular Characterization of Angiotensin-Converting Enzyme (ACE)-Inhibitory Peptides from Takifugu flavidus. Marine drugs, 21(10), 522–536. https://doi.org/10.3390/md21100522
Tacias-Pascacio, V. G., Morellon-Sterling, R., Siar, E. H., Tavano, O., Berenguer-Murcia, Á., & Fernandez-Lafuente, R. (2020). Use of Alcalase in the production of bioactive peptides: A review. International journal of biological macromolecules, 165, 2143-2196. https://doi.org/10.1016/j.ijbiomac.2020.10.060
Tak, Y., Kaur, M., Amarowicz, R., Bhatia, S. & Gautam, C. (2021). Pulse Derived Bioactive Peptides as Novel Nutraceuticals: A Review. International journal of peptide research and therapeutics, 27(3), 2057-2068. https://doi.org/10.1007/s10989-021-10234-8
Tawalbeh, D., Al-U’datt, M. H., Wan-Ahmad, W. A. N., Ahmad, F., & Sarbon, N. M. (2023). Recent Advances in In Vitro and In Vivo Studies of Antioxidant, ACE-Inhibitory and Anti-Inflammatory Peptides from Legume Protein Hydrolysates. Molecules, 28(6), 2423-2446. https://doi.org/10.3390/molecules28062423
Torruco-Uco, J., Chel-Guerrero, L., Martínez-Ayala, A., Dávila-Ortíz, G., & Betancur-Ancona, D. (2009). Angiotensin-I converting enzyme inhibitory and antioxidant activities of protein hydrolysates from Phaseolus lunatus and Phaseolus vulgaris seeds. LWT, 42(10), 1597-1604. https://doi.org/10.1016/j.lwt.2009.06.006
Udeh, C., Ifie, I., Akpodiete, J., & Malomo, S. (2021). Kidney bean protein products as potential antioxidative and antihypertensive alternatives for non-pharmacological inhibition of angiotensin-converting enzymes. Scientific African, 11, e00693–e00715. https://doi.org/10.1016/j.sciaf.2021.e00693
Ulug, S. K., Jahandideh, F., & Wu, J. (2021). Novel technologies for the production of bioactive peptides. Trends in food science & technology, 108, 27–39. https://doi.org/10.1016/j.tifs.2020.12.002
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009). Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Current neuropharmacology, 7(1), 65-74. https://doi.org/10.2174/157015909787602823
Valdez-Ortiz, A., Fuentes-Gutiérrez, C. I., Germán-Báez, L. J., Gutiérrez-Dorado, R., & Medina-Godoy, S. (2012). Protein hydrolysates obtained from Azufrado (sulphur yellow) beans (Phaseolus vulgaris): Nutritional, ACE-inhibitory and antioxidative characterization. LWT, 46(1), 91-96. https://doi.org/10.1016/j.lwt.2011.10.021
Valencia-Mejía, E., Batista, K. A., Fernández, J. J. A., & Fernandes, K. F. (2019). Antihyperglycemic and hypoglycemic activity of naturally occurring peptides and protein hydrolysates from easy-to-cook and hard-to-cook beans (Phaseolus vulgaris L.). Food research international, 121, 238-246. https://doi.org/10.1016/j.foodres.2019.03.043
Vignesh, A., Amal, T. C., Sarvalingam, A., & Vasanth, K. (2024). A review on the influence of nutraceuticals and functional foods on health. Food chemistry advances, 5, 100749.https://doi.org/10.1016/j.focha.2
100749
Wang, Y. & Wang, J. (2020). Modelling and prediction of global noncommunicable diseases. BMC public health, 20(1), 822. https://doi.org/10.1186/s12889-020-08890-4
Wei, H., Xiao, Y., Tong, Y., Chen, Y., Luo, X., Wang, Y., Jin, P., Ma, C., Fu, Z., Guo, H., Zhao, X., & Li, Y. (2019). Therapeutic effect of angelica and its compound formulas for hypertension and the complications: Evidence mapping. Phytomedicine, 59, 152767-152794. https://doi.org/10.1016/j.phymed.2018.11.027
Wen, C., Zhang, J., Zhang, H., Duan, Y., & Ma, H. (2020). Plant protein-derived antioxidant peptides: Isolation, identification, mechanism of action and application in food systems: A review. Trends in food science & technology, 105, 308–322. https://doi.org/10.1016/j.tifs.2020.09.019
WHO, World health statistics (2023). World Health Statistics 2023: Monitoring Health for the SDGs, Sustainable Development Goals. World Health Organization. [En línea]. Disponible en: https://reliefweb.int/report/world/world-health-statistics-2023-monitoring-health-sdgs-sustainable-developmentgoals?gad_source=1&gclid=CjwKCAiAlcyuBhBnEiwAOGZ2S9HCWFC6XncrPKW5OLUHDQ38OXeAKLAdOeJgqlZPscHTBQ1xUIBHBoCCSIQAvD_BwE Fecha de consulta: 22 de enero de 2024.
Xiang, L., Qiu, Z., Zhao, R., Zheng, Z., & Qiao, X. (2023). Advancement and prospects of production, transport, functional activity and structure-activity relationship of food-derived angiotensin converting enzyme (ACE) inhibitory peptides. Critical reviews in food science and nutrition, 63(10), 1437-1463. https://doi.org/10.1080/10408398.2021.1964433
Yang, F., Chen, X., Huang, M., Yang, Q., Cai, X., Chen, X., Du, M., Huang, J., & Wang, S. (2021). Molecular characteristics and structure–activity relationships of food-derived bioactive peptides. Journal of integrative agriculture, 20(9), 2313-2332. https://doi.org/10.1016/S2095-3119(20)63463-3
Yuan, H., Luo, Z., Ban, Z., Reiter, R. J., Ma, Q., Liang, Z., Yang, M., Li, X., & Li, L. (2022). Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health. Food & function, 13(6), 3133-3158. https://doi.org/10.1039/D1FO04077D
Zamyatnin, A. A. (2018). Structural–functional diversity of the natural oligopeptides. Progress in Biophysics and molecular biology, 133, 1-8. https://doi.org/10.1016/j.pbiomolbio.2017.09.024
Zheng, Z., Li, J., Li, J., Sun, H., & Liu, Y. (2019). Physicochemical and antioxidative characteristics of black bean protein hydrolysates obtained from different enzymes. Food hydrocolloids, 97, 105222-105235. https://doi.org/10.1016/j.foodhyd.2019.105222
Zhu, F., Cao, J., Song, Y., Yu, P., & Su, E. (2023). Plant Protein-Derived Active Peptides: A Comprehensive Review. Journal of agricultural and food chemistry, 71(51), 20479-20499. https://doi.org/10.1021/acs.jafc.3c06882
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